5α-Reductase Inhibitory Potential of <i>Hibiscus rosa sinensis</i>: Effective for the Management of Alopecia

The condition known as male pattern hair loss and benign prostatic hyperplasia are both treated with a family of drugs 5 alpha reductase (5α-reductase) inhibitors. This study shows that the flower Hibiscus rosa sinensis has 5α-reductase inhibitory action is helpful in treatment androgenic diseases. Phytochemical screening was done using petroleum ether, methanol, water extracts to identify phytochemical group present. Then, quercetin reference flavonoid component, Total Flavonoid Content (TFC) assessed colorimetric technique. activity evaluated several compared well-known inhibitor finasteride. Finally, inhibition different enzyme biochemical approach measure 5α-reductase. It determined IC<sub>50</sub> value methanolic extract, 146.048 ± 0.453 (μg/mL) (a chemical biomarker plant material) 141.426 1.578 (μg/mL), were promising candidates for future investigation into their antiandrogenic activities.